The Philadelphia Union will host the New York Red Bulls in a 2025 U.S. Open Cup quarterfinal clash on Wednesday on Paramount+. These familiar foes sit third and seventh in the MLS Eastern Conference standings, and are facing each other for the first time this year in any competition. Philadelphia is returning home after tallying back-to-back league losses on the road, while New York just settled for three straight draws in MLS play. The latest Philadelphia Union vs. New York Red Bulls odds from DraftKings list the hosts as the +100 favorites on the 90-minute money line, with New York as the +240 underdogs. A draw is priced at +245, and the over/under for total goals is 2.5. Before locking in any New York Red Bulls vs. Philadelphia Union picks, you need to see what proven SportsLine soccer expert Brandt Sutton has to say. Sutton was profitable across multiple leagues for SportsLine subscribers in 2023, including the Champions League, English Premier League, Europa League, FA Cup and more. He also finished 2022 as SportsLine's No. 1 soccer betting expert with a 165-130-2 mark, returning nearly $2,200 for $100 players. Brandt Sutton's U.S. Open Cup picks and predictions for Philadelphia Union vs. New York Red Bulls include under 2.5 goals and Philadelphia Union on the money line. The expert notes that under 2.5 goals have been scored in four of the Union's last five fixtures overall, while under 2.5 has hit in four of the Red Bulls' last five away matches. Additionally, under 2.5 goals have been scored in 10 of the last 11 meetings between these teams across all competitions. The Union have registered nine wins and five draws over their last 14 meetings against the Red Bulls. Philadelphia has lost just one home match in league play this season, and secured a dominant 4-1 victory at home against Pittsburgh Riverhounds SC in the U.S. Open Cup Round of 16 on May 21. Kickoff from Subaru Park in Chester, Pa., is set for 7 p.m. ET. Stream the match live on Paramount+, which you can now try free for the first seven days when you sign up. And don't forget to catch the full analysis on the CBS Sports Golazo Network. So, who will win this U.S. Open Cup quarterfinal match? The Philadelphia Union is looking to bounce back from two consecutive road losses, while the New York Red Bulls are trying to break their streak of three straight draws. But with the expert picks from Brandt Sutton, you can make an informed decision. The match will be a thrilling encounter between two teams that are familiar with each other. The Philadelphia Union's home advantage could play a significant role in the outcome of the match. The team's recent performance in the U.S. Open Cup has been impressive, and they will look to continue their winning streak. The New York Red Bulls, on the other hand, will try to capitalize on the Union's recent losses and secure a win. The stage is set for an exciting match, and the outcome is far from certain. But with the expert analysis and picks from Brandt Sutton, you can get a better understanding of the teams' chances and make a more informed decision.